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Even though owning no narcotic effects of its individual, the significant opioid precursor thebaine differs from codeine only slightly in framework. Pseudocodeine and Various other identical alkaloids not now Employed in medicine are located in trace quantities in opium at the same time.
It's As a result authorized to possess codeine with out a prescription, furnished that it's compounded with a minimum of a single other active or inactive ingredient and that the dosage of every tablet, capsule, and so on. won't exceed 100 mg or 2.five% focus in the case of liquid preparations. The exemptions don't to apply to any planning of codeine designed for injection.[100]
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The existence of the polymorphism in CYP2D6 is connected to lousy metabolism of codeine and not enough therapeutic reaction from codeine.
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